Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results	Reference
1	J:182789 Abe K, Naruse C, Kato T, Nishiuchi T, Saitou M, Asano M, Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice. Biol Reprod. 2011 Nov;85(5):1013-24
1*	J:184591 Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y, Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
1	J:90769 Aubin J, Davy A, Soriano P, In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 2004 Jun 15;18(12):1482-94
1	J:76369 Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T, Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47
1	J:234992 Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RP, Apte SS, Haltiwanger RS, Holdener BC, Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. Dev Biol. 2016 Aug 1;416(1):111-22
1*	J:302463 Buers I, Pennekamp P, Nitschke Y, Lowe C, Skryabin BV, Rutsch F, Lmbrd1 expression is essential for the initiation of gastrulation. J Cell Mol Med. 2016 Aug;20(8):1523-33
1	J:277240 Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW, Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PLoS One. 2019;14(7):e0219221
1	J:181474 Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A, LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
1	J:239417 Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL, TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
1*	J:148775 Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O, BMP and BMP receptor expression during murine organogenesis. Gene Expr Patterns. 2009 Jun;9(5):255-65
1	J:98382 Donnison M, Beaton A, Davey HW, Broadhurst R, L'huillier P, Pfeffer PL, Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. Development. 2005 May;132(10):2299-308
1*	J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
1	J:89189 Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK, Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development. 2004 Apr;131(8):1717-28
1	J:154368 Farkas DR, Chapman DL, Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes. Dev Dyn. 2009 Oct 29;238(12):3237-3247
1	J:165811 Fernandez-Diaz LC, Laurent A, Girasoli S, Turco M, Longobardi E, Iotti G, Jenkins NA, Fiorenza MT, Copeland NG, Blasi F, The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development. 2010 Oct;137(20):3393-403
1*	J:131814 Fukusumi Y, Naruse C, Asano M, Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 2008 Mar;237(3):618-29
1	J:54394 Gu Z, Reynolds EM, Song J, Lei H, Feijen A, Yu L, He W, MacLaughlin DT , van den Eijnden-van Raaij J , Donahoe PK , Li E, The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development. 1999 Jun;126(11):2551-61
1	J:119566 Ishimura A, Ng JK, Taira M, Young SG, Osada S, Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development. 2006 Oct;133(19):3919-28
1	J:91055 Kelly OG, Pinson KI, Skarnes WC, The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
1	J:74124 Kinder SJ, Tsang TE, Ang SL, Behringer RR, Tam PP, Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol. 2001;45(1 Spec No):347-55
1	J:59069 Klingensmith J, Ang SL, Bachiller D, Rossant J, Neural induction and patterning in the mouse in the absence of the node and its derivatives. Dev Biol. 1999 Dec 15;216(2):535-49
1	J:147414 Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C, Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet. 2008 Oct;4(10):e1000241
1*	J:204971 Li L, Liu C, Biechele S, Zhu Q, Song L, Lanner F, Jing N, Rossant J, Location of transient ectodermal progenitor potential in mouse development. Development. 2013 Nov;140(22):4533-43
1	J:132584 Liguori GL, Borges AC, D'Andrea D, Liguoro A, Goncalves L, Salgueiro AM, Persico MG, Belo JA, Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol. 2008 Mar 15;315(2):280-9
1	J:56511 Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR, Bradley A, Requirement for Wnt3 in vertebrate axis formation. Nat Genet. 1999 Aug;22(4):361-5
1*	J:137199 Lupu F, Alves A, Anderson K, Doye V, Lacy E, Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell. 2008 Jun;14(6):831-42
1*	J:236404 Minocha S, Bessonnard S, Sung TL, Moret C, Constam DB, Herr W, Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. Dev Biol. 2016 Oct 1;418(1):75-88
1	J:177114 Miura S, Mishina Y, Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo. Dev Dyn. 2011 Nov;240(11):2474-81
1	J:121791 Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I, One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics. 2007 Jun;89(6):687-696
1*	J:195277 Nakamura H, Cook RN, Justice MJ, Mouse Tenm4 is required for mesoderm induction. BMC Dev Biol. 2013;13:9
1*	J:53656 Perea-Gomez A, Shawlot W, Sasaki H, Behringer RR, Ang S, HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development. 1999 Oct;126(20):4499-511
1	J:81339 Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL, Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell. 2002 Nov;3(5):745-56
1	J:205747 Polydorou C, Georgiades P, Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
1	J:157256 Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D, Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 2010 Jan;137(2):249-59
1*	J:18543 Rashbass P, Wilson V, Rosen B, Beddington RS, Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos. Int J Dev Biol. 1994 Mar;38(1):35-44
1	J:272362 Su X, Wu C, Ye X, Zeng M, Zhang Z, Che Y, Zhang Y, Liu L, Lin Y, Yang R, Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death Dis. 2018 Feb 21;9(3):302
1*	J:166847 Tonissoo T, Lulla S, Meier R, Saare M, Ruisu K, Pooga M, Karis A, Nucleotide exchange factor RIC-8 is indispensable in mammalian early development. Dev Dyn. 2010 Dec;239(12):3404-15
1*	J:186556 Trask MC, Tremblay KD, Mager J, Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012 Aug 15;368(2):273-82
1*	J:71998 Tremblay KD, Dunn NR, Robertson EJ, Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001 Sep;128(18):3609-21
1	J:155112 Tsiairis CD, McMahon AP, An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009 Dec 1;19(22):1912-7
1	J:146397 Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y, GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell. 2007 Oct;18(10):3764-75
1*	J:49084 Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX, Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9378-83
1*	J:28717 Winnier G, Blessing M, Labosky PA, Hogan BL, Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995 Sep 1;9(17):2105-16
1	J:103454 Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME, Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo. BMC Dev Biol. 2005 Aug 18;5:17
1*	J:86912 Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S, Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 1;17(23):2933-49
1	J:177837 Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainen T, Vainio S, Tryggvason K, Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn. 2011 Dec;240(12):2646-56
1	J:111701 Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM, Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84
1*	J:63160 Ying Y, Liu XM, Marble A, Lawson KA, Zhao GQ, Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Mol Endocrinol. 2000 Jul;14(7):1053-63